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Authors
Affiliations
1 Bapatla College of Pharmacy,
Bapatla-522101, IN
2 Bapatla College of Pharmacy, Bapatla-522101, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 1 (2012), Pagination: 52-55
Abstract
The present investigation deals with formulation of valsartan fast dissolving tablets using co processed superdisintegrant. Crospovidone and SSG were used for preparation of co processed superdisintegrant by physical mixing and solvent evaporation method in three different ratios (1:1, 1:2, and 1:3). Six formulations are formulated with co processed superdisintegrant and are evaluated for weight variation, hardness, wetting time, water absorption ratio, disintegration time and dissolution studies and all formulations complies with pharmacoepial standards. Formulation made with co processed crospovidone and SSG in 1:1 ratio was found to be best out of all formulations. Present investigation concludes dissolution rate of valsartan fast dissolving tablets were influenced by ratios of individual superdisintegrants employed for co processed superdisintegrant and method used for preparation of co processed superdisintegrant (physical mixing vs solvent evaporation).
Keywords
Valsartan, Crospovidone, Sodium Starch Glycolate, Co-Processing.
